Wellbutrin weight loss reddit

Wellbutrin weight loss reddit

Side effects. FAQs. Wellbutrin and weight loss. Dosage. Wellbutrin for ADHD. Wellbutrin and anxiety. Alternatives. Interactions. Wellbutrin and alcohol. Withdrawal and dependence. Uses....Feb 15, 2024 · Zoloft, containing the active ingredient sertraline, is a selective serotonin reuptake inhibitor (SSRI). Zoloft works by increasing levels of serotonin in the brain. Serotonin is a chemical messenger associated with mood, memory, and many other behaviors. Zoloft is available in the following forms of administration: The Mayo Clinic Diet: What is your weight-loss goal? 5-10. Side Effects. Drug information provided by: Merative, Micromedex®. Along with its needed effects, a ...Wellbutrin (bupropion) and Zoloft (sertraline) are both low-cost antidepressants that can help with more than just depression. But they have different drug interactions because of how they work in the body. They also both have potential side effects. Zoloft tends to cause nausea and sexual side effects more often, while Wellbutrin is more ...The only side effect that remains is the loss of appetite. I don't get hungry but when I do, the smell/taste/sight is a turn off. I struggle through it (LOL - sounds funny). I'm down 18 lbs. I am still in the 'overweight' stage per BMI so, for me, losing weight isn't a horrible thing. My guess is that, like the other side effects, this too ...Jun 27, 2022 ... For instance, she says that if you're taking an SSRI, “switching to fluoxetine [Prozac] could be helpful. Considering a trial of bupropion [ ... I’m in my early 20s and take 2000mg Metformin to regulate my hormones and also 400mg of the antidepressant Wellbutrin (which can cause appetite suppression). The Metformin has caused my periods to finally be regular for the first time in my life. So here is the issue. The combination of both of these medications has caused me to go from 160 ... Oprah Winfrey is an iconic figure in the world of entertainment, but she is also known for her incredible weight loss success. Over the years, Oprah has been open about her struggl...Nov 7, 2023 · A 2020 review of 21 studies on metformin and weight loss found that metformin results in a statistically significant reduction of BMI in individuals with obesity, and otherwise moderately reduces ...If you need to stop taking Wellbutrin, follow your doctor’s instructions on how to safely stop taking it. They may slowly lower your dose over 6 to 8 weeks to prevent withdrawal symptoms. This is called tapering down. The American Psychiatric Association recommends that all antidepressants be tapered down to lower the risk of withdrawal …Feb 23, 2024 · The recommended starting dose for SAD is 150 mg once daily. After 7 days of dosing, the dose may be increased to the target dose of 300 mg once daily in the morning. Doses above 300 mg of bupropion hydrochloride extended-release were not assessed in the SAD trials. For the prevention of seasonal MDD episodes associated with SAD, initiate ... Nov 7, 2023 · A 2020 review of 21 studies on metformin and weight loss found that metformin results in a statistically significant reduction of BMI in individuals with obesity, and otherwise moderately reduces ...Prozac made me a zombie. Wellbutrin helped me lose weight and gave me enough energy to move around. Work closely with your psych. Wellbutrin should help with appetite but it might be hard anxiety wise. jeepers222. •. As others have said, it's so hard to say given people react differently to medications.Antidepressants and Weight Loss. Antidepressants linked to weight loss include Prozac (fluoxetine) and Wellbutrin (bupropion). People taking Effexor (venlafaxine) may experience a quick loss of a small amount of weight, and in a 10-year-long study, Effexor was associated with below-average weight gain. A link implies a statistical …Jan 12, 2024 · One review found hair loss was more common with valproic acid (Depakote) and pregabalin (Lyrica), but less common with levetiracetam (Keppra). 5. Beta blockers. Beta blockers are a class of medications that treat high blood pressure and other heart conditions. Beta blockers can cause telogen effluvium, but it’s not common.The most common symptoms are vomiting, diarrhea, and nausea, which affect anywhere from 2 to 63 percent of people on the drug. Discomfort can be so severe that you may not feel like eating much ...Most cases resolve on discontinuation of Wellbutrin (bupropion); however, a few may persist. More likely than other antidepressants to cause weight loss; however, may also …Apr 17, 2023 · The recommended starting dose is 200 mg per day, given as 100 mg twice daily. After 3 days of dosing, the dose may be increased to 300 mg per day, given as 100 mg 3 times daily, with at least 6 hours between successive doses. Dosing above 300 mg per day may be accomplished using the 75- or 100-mg tablets. A maximum of 450 mg per day, given in ... Applies to: Wellbutrin (bupropion) Using buPROPion and nicotine together can cause an increase in blood pressure. This can cause dizziness, confusion, uneven heartbeats, and chest pain. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked ... See also Warning section. Dry mouth, sore throat, dizziness, nausea, vomiting, ringing in the ears, headache, decreased appetite, weight loss, constipation, trouble sleeping, increased sweating ... Jun 11, 2018 · 7. You don't even want to think about food. #MentalHealth Update: other side effects of the Wellbutrin have kicked in. Namely: not feeling hungry, better focus. :D. While it’s less common ...Wellbutrin XL (bupropion) for Depression "Real and honest review. I’m a 52 yo male living in Canada. ... For Anti-obesity Medications for Weight Loss (Obesity/Overweight) "Naltrexone hcl 50 mg 1/2 tab daily & Bupropion hcl er (SR)12hr 150 mg 1 tab daily for 14 days then 2 tab daily thereafter. I'm 5.6, 270 LBS with High blood …Wellbutrin and weight loss. Weight loss is a common side effect of Wellbutrin, affecting 14% to 23% of people who take the medication. Anorexia—loss of appetite—is also commonly experienced, with an incidence between 1% and 18%. ... To avoid weight loss or weight gain, eat a healthy diet and carefully monitor weight while …Apr 6, 2023 · Weight changes are considered a side effect for both Wellbutrin XL and Wellbutrin SR. Studies of Wellbutrin XL show that 23% of people taking a dose of 150 to 300 mg per day lost 5 pounds or more. In the same studies, 11% of people gained more than 5 pounds. Studies of Wellbutrin SR show that 14% of people taking a dose of 300 mg per day lost ... Official answer. by Drugs.com. Wellbutrin XL and Wellbutrin SR are different formulations of the antidepressant bupropion. Both Wellbutrin XL and Wellbutrin SR …The problem of carrying unwanted weight on your frame is unfortunately common. While some people simply are unhappy with the way that their clothes fit, others are clinically obese...Wellbutrin -Bupropion , all things related to this antidepressant. Zyban. Norepinephrine–dopamine reuptake inhibitor (NDRI) , major depressive disorder, atypical antidepressant , Epileptic seizures , ADHD, alleviate sexual dysfunction, weight loss, releasing agent of dopamine and norepinephrine (NDRA), similarly to other cathinones , …Nov 3, 2023 ... The FDA has also approved a medication called Contrave, which is a combination of bupropion and naltrexone, for weight loss. It is intended to ...Ease of Use. Satisfaction. Wellbutrin gave me energy almost immediately (Day 2) which felt amazing since my depression was making me tired and unmotivated to do anything. With the burst of energy also came loss of appetite and the inability to sleep for more than 5 hours a night. Fortunately, the loss of appetite faded after about 4 months and ...Diets are only effective if your body never thinks the diet is over. Obesity is a risk factor for numerous disorders that afflict the human race, so understanding how to maintain a...Dec 5, 2023 · Wellbutrin is an antidepressant medication that treats depression and seasonal affective disorder. Common Wellbutrin side effects include tremors, agitation, and dry mouth. It can also cause dizziness, constipation, and increased sweating. But Wellbutrin is less likely than other antidepressants to cause sexual side effects and weight gain. Nov 15, 2004 · Weight gain would be an expected consequence of antidepressants with affinity for histamine and/or 5-HT 2C receptors. Bupropion has no relevant affinity for these receptors and is not associated with weight gain. It is typically associated with a slight weight loss (e.g., approximately equal to 1.5 kg with initial treatment). Jun 11, 2018 · 7. You don't even want to think about food. #MentalHealth Update: other side effects of the Wellbutrin have kicked in. Namely: not feeling hungry, better focus. :D. While it’s less common ...Jun 27, 2022 ... For instance, she says that if you're taking an SSRI, “switching to fluoxetine [Prozac] could be helpful. Considering a trial of bupropion [ ...Prozac made me a zombie. Wellbutrin helped me lose weight and gave me enough energy to move around. Work closely with your psych. Wellbutrin should help with appetite but it might be hard anxiety wise. jeepers222. •. As others have said, it's so hard to say given people react differently to medications. This is an energizing antidepressant and because I had gained 25 lbs in last 2 years I was excited to try something that could potentially curb my desire to stress eat and snack. I had started at 167lbs and dropped to 162lbs in 8 weeks before starting Wellbutrin. In the last 3 weeks, i'm already down to 157lbs. Crohn’s disease, also known as regional ileitis or ileitis terminalis, is an inflammatory bowel disease (IBD) that can affect any part of your gastrointestinal tract. It causes var...The usual adult target dose for WELLBUTRIN SR is 300 mg/day, given as 150 mg twice daily. Initiate dosing with 150 mg/day given as a single daily dose in the morning. After 3 days of dosing, the dose may be increased to the 300-mg/day target dose, given as 150 mg twice daily. There should be an interval of at least 8 hours between …Jan 16, 2024 · Official answer. Zoloft (sertraline) may lead to a small weight gain ranging from 1% to 1.6% of initial body weight when used over 6 months to 1 year. For example, in a 150 lb (68 kg) person, this would equal an added 1.5 to 2.4 lbs (0.7 to 1.1 kg) of weight. Shorter-term treatment in adults usually does not lead to substantial weight gain, but ...For people who have taken Wellbutrin before for different reasons, have you lost weight on it? I noticed a decrease in the need for snacking but did not have crazy weight loss. I’ve …For people who have taken Wellbutrin before for different reasons, have you lost weight on it? I noticed a decrease in the need for snacking but did not have crazy weight loss. I’ve …Wellbutrin starts improving symptoms within one to weeks of the initial dose. However, it usually takes around six to eight weeks to work effectively as a treatment for depression. This article will highlight how long Wellbutrin takes to work, how it works, and other significant details regarding the safe and effective use of Wellbutrin.Jul 27, 2023 · May increase blood sugar levels. People with a history of diabetes or at risk of diabetes should be monitored closely. May also cause undesirable changes in blood cholesterol and lipid levels or weight loss or gain. Leukopenia, neutropenia, and agranulocytosis have been reported with antipsychotic agents including Caplyta.Wellbutrin, an antidepressant that can spur weight loss and boost libido, is on everyone's lips. Sari Botton reveals why she's on auto-refill. By Sari Botton Published: Feb 19, 2014In both cases, the maintenance of high levels of norepinephrine can make it feel like your nervous system is a little ‘wired’ - for me that’s an exciting feeling I like. Wellbutrin also has a dopamine reuptake inhibitor, so you get the good mood for free. It lowers the retrieval cost for thoughts, and memories.Oprah Winfrey is an iconic figure in the world of entertainment, but she is also known for her incredible weight loss success. Over the years, Oprah has been open about her struggl...Jul 27, 2023 · May increase blood sugar levels. People with a history of diabetes or at risk of diabetes should be monitored closely. May also cause undesirable changes in blood cholesterol and lipid levels or weight loss or gain. Leukopenia, neutropenia, and agranulocytosis have been reported with antipsychotic agents including Caplyta.Student Organization Resource Center (SORC) Student Conduct. Student Health ServiceSubjects who completed 48 weeks maintained mean losses of initial body weight of 7.5% and 8.6% for bupropion SR 300 and 400 mg/d, respectively. Discussion: Bupropion SR 300 and 400 mg/d were well-tolerated by obese adults and were associated with a 24-week weight loss of 7.2% and 10.1% and sustained weight losses at 48 weeks.Wellbutrin has an average rating of 6.7 out of 10 from a total of 742 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 23% reported a negative effect. Zoloft has an average rating of 7.2 out of 10 from a total of 1935 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 19% reported a negative effect.Wegovy is one of several drugs that promise substantial weight loss. But patient experiences, along with shifting perspectives on excess weight in medicine, call into question what... Wellbutrin is supposed to decrease your appetite but everyone is different. Keep in mind, with any SSRI you'll most likely have some funky but temporary side effects for the first 6 weeks. You won't really know how it affects your appetite until you're one or two months into it. OvaryQuiver. •. . The Mayo Clinic Diet: What is your weight-loss goal? 5-10. Side Effects. Drug information provided by: Merative, Micromedex®. Along with its needed effects, a ...In the fall I started an SSRI for Anxiety and it definitely helped stop my panic attacks which is a total game-changing life-saver, but it has also shot my weight loss in the foot. Since starting it, I've gained 17 lbs which pretty much sucks. Today my psychiatrist recommended adding Wellbutrin which is supposed to help as an appetite ...Apr 15, 2015 · In all studies, naltrexone/bupropion combined with a diet and exercise program for one year resulted in greater weight loss than placebo combined with a diet and exercise program. 2 – 5 About ... Wellbutrin is supposed to decrease your appetite but everyone is different. Keep in mind, with any SSRI you'll most likely have some funky but temporary side effects for the first 6 weeks. You won't really know how it affects your appetite until you're one or two months into it. OvaryQuiver. •. Overall rating 5.0. Effectiveness. Ease of Use. Satisfaction. I lived with depression 1/2 my life. My doctor prescribed Wellbutrin XL and the 1st pill I took I could feel the depression leave my body like a ghost leaving my body. I took it for years with no side effects. I have tried other meds that did nothing.Mar 1, 2019 · Wellbutrin is an antidepressant medication that has several on- and off-label uses. You may also see it referred to by its generic name, bupropion. Medications can affect people in different ways ... In the ever-evolving landscape of weight management strategies, a notable trend has emerged: the exploration of Wellbutrin as a potential solution for achieving weight loss goals. This introduction lays the groundwork for understanding how this antidepressant medication has garnered attention for its potential role in weight …Same diet and exercise as before. Was not feeling hungry/ had desire to eat but had to force myself to eat so im not sure how i still gained weight. Jan. 23, 2023- weight: 124lbs - increased to 100mg Sertraline + started taking 150mg Bupropion XL. This is where i really noticed that my weight is ballooning like crazy.A 2004 Wellbutrin ad, published in the wake of a 2002 study that found statistically significant rates of weight loss associated with Wellbutrin, directly targeted patients already on traditional antidepressants who might be dissatisfied by their current side effects like weight gain and dampened libido. The ad depicts a woman laughing in the ...Losing weight can be a challenging journey, but with the right weight loss program, you can achieve your goals and maintain a healthy lifestyle. With so many programs available, it...Bupropion has an average rating of 7.4 out of 10 from a total of 43 reviews for the off-label treatment of Anti-obesity Medications for Weight Loss (Obesity/Overweight). 70% of …Jan 12, 2023 · Weight loss medications that you take as a pill are a convenient, needle-free option for people who need help to lose excess body weight. Typically, people can lose up to 5% to 10% of their body weight on these medications.. Prescription-only pills that are FDA approved for weight loss are summarized below. They’re most effective when combined … Overall rating 5.0. Effectiveness. Ease of Use. Satisfaction. I lived with depression 1/2 my life. My doctor prescribed Wellbutrin XL and the 1st pill I took I could feel the depression leave my body like a ghost leaving my body. I took it for years with no side effects. I have tried other meds that did nothing. It increases the amount of insulin your body produces and decreases cell resistance, resulting in lower blood sugar. “Berberine helps with two things,” Dr. Bradley says. It improves: Your ...Mar 1, 2024 · Wellbutrin XL®: At first, 150 mg once a day in the morning. Your doctor may adjust your dose as needed. However, the dose is usually not more than 450 mg per day. Children—Use and dose must be determined by your doctor. For seasonal affective disorder: Adults— Aplenzin®: At first, 174 milligrams (mg) once a day in the morning. Mar 20, 2023 · The maximum dosage of Wellbutrin SR is 400 mg per day. The starting dosage of Wellbutrin XL is 150 mg once per day. After 4 days, your doctor might increase your dosage to 300 mg once per day ... Wellbutrin can come with side effects such as a fast or irregular heartbeat, racing thoughts, and increased energy that might make it difficult to fall asleep (via RxList). Although you …Wellbutrin -Bupropion , all things related to this antidepressant. Zyban. Norepinephrine–dopamine reuptake inhibitor (NDRI) , major depressive disorder, atypical antidepressant , Epileptic seizures , ADHD, alleviate sexual dysfunction, weight loss, releasing agent of dopamine and norepinephrine (NDRA), similarly to other cathinones , …7. You don't even want to think about food. #MentalHealth Update: other side effects of the Wellbutrin have kicked in. Namely: not feeling hungry, better focus. :D. While it’s less common ...dry mouth. nausea. constipation. insomnia (trouble falling asleep or staying asleep) These are only a few of the side effects that can occur with Wellbutrin. In the …Wellbutrin is supposed to decrease your appetite but everyone is different. Keep in mind, with any SSRI you'll most likely have some funky but temporary side effects for the first 6 weeks. You won't really know how it affects your appetite until you're one or two months into it. OvaryQuiver. •.Apply cider vinegar may help with weight loss if you drink a small amount before meals. Dilute the vinegar in water and drink prior to eating. Most any vinegar works for weight los...Feb 23, 2024 · The recommended starting dose for SAD is 150 mg once daily. After 7 days of dosing, the dose may be increased to the target dose of 300 mg once daily in the morning. Doses above 300 mg of bupropion hydrochloride extended-release were not assessed in the SAD trials. For the prevention of seasonal MDD episodes associated with SAD, initiate ... Nov 9, 2023 · The specific amount of weight you might lose from Zepbound is uncertain, but significant weight loss ranging from 35.5 lb (16.1 kg) to 52.0 lb (23.6 kg) was observed in the 72-week SURMOUNT-1 clinical trial, which compared different Zepbound (tirzepatide) doses to a placebo (inactive treatment). Zepbound is administered once a week through …Crohn’s disease, also known as regional ileitis or ileitis terminalis, is an inflammatory bowel disease (IBD) that can affect any part of your gastrointestinal tract. It causes var...Sep 21, 2022 · But taking phentermine has risks, including potential drug interactions. Phentermine may interact with antidepressants like MAOIs, SSRIs, and SNRIs. It may also interact with Fintepla, other weight loss medications, and alcohol. Before starting phentermine, talk with your healthcare provider or pharmacist.the sustained-release formulation of bupropion, patients experienced weight gain or weight loss ... The most common side effects of WELLBUTRIN XL are weight loss, ... During the pandemic I got to my lowest point so I decided to try. My psych first put me on Lexapro which made me gain a lot of weight and have no feelings, which I didn’t like. After Lexapro, I switched to Wellbutrin XL 150mg and it’s literally changed my life. I’m on 300 XL now. Mild side effects. Serious side effects. FAQs. Specifics. Precautions. Talk with your doctor. Overview. Wellbutrin (bupropion hydrochloride) is a brand-name …Wegovy is one of several drugs that promise substantial weight loss. But patient experiences, along with shifting perspectives on excess weight in medicine, call into question what...Ease of Use. Satisfaction. Wellbutrin gave me energy almost immediately (Day 2) which felt amazing since my depression was making me tired and unmotivated to do anything. With the burst of energy also came loss of appetite and the inability to sleep for more than 5 hours a night. Fortunately, the loss of appetite faded after about 4 months and ...Diets are only effective if your body never thinks the diet is over. Obesity is a risk factor for numerous disorders that afflict the human race, so understanding how to maintain a...They helped ease anxiety and depression, but they nuked my linido, weakened my orgasms significantly, and caused delayed ejaculation (took 1-2 hrs for very weak feeling orgasm). The first few months on Wellbutrin have been rocky with increased anxiety, almost no appetite, anger, jaw clenching, and a few other side effects that have since subsided.Applies to: Wellbutrin (bupropion) and Cymbalta (duloxetine) Talk to your doctor before using buPROPion together with DULoxetine. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. In addition, buPROPion can increase the blood levels of DULoxetine, which may increase other side effects.Feb 23, 2024 · The recommended starting dose for SAD is 150 mg once daily. After 7 days of dosing, the dose may be increased to the target dose of 300 mg once daily in the morning. Doses above 300 mg of bupropion hydrochloride extended-release were not assessed in the SAD trials. For the prevention of seasonal MDD episodes associated with SAD, initiate ... 2 days ago · For people who have taken Wellbutrin before for different reasons, have you lost weight on it? I noticed a decrease in the need for snacking but did not have crazy weight loss. I’ve lost 70 pounds. This is an energizing antidepressant and because I had gained 25 lbs in last 2 years I was excited to try something that could potentially curb my desire to stress eat and snack. I had started at 167lbs and dropped to 162lbs in 8 weeks before starting Wellbutrin. In the last 3 weeks, i'm already down to 157lbs. Hi all, I've been on Bupropion for 6 weeks now. 150mg for 4 weeks and 300mg for 2 weeks. So far, I've not had any discernible benefits. Here's how I feel. Pros: Anxiety has lessened. This was a real problem for me in the first 3-4 weeks. No longer feeling physical side effects. Qsymia works by reducing your appetite. In initial studies, Qsymia helped about 70% of adults lose at least 5% of their body weight after 1 year. Close to 50% of participants lost at least 10% of their body weight. When compared to Contrave, researchers found that Qsymia is usually the more effective option. 3.Wellbutrin has an average rating of 6.7 out of 10 from a total of 742 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 23% reported a negative effect. Zoloft has an average rating of 7.2 out of 10 from a total of 1935 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 19% reported a negative effect.I was on 100mg of wellbutrin for 1 year, and I saw a 10 lbs loss (which I gained because of COVID, stress, and zoloft). I eventually titrated up to 450, and in 2 months I've lost 11 lbs …Fluoxetine has an average rating of 7.3 out of 10 from a total of 2166 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 18% reported a negative effect. Wellbutrin XL has an average rating of 7.5 out of 10 from a total of 482 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 15% reported a negative ...Most cases resolve on discontinuation of Wellbutrin (bupropion); however, a few may persist. More likely than other antidepressants to cause weight loss; however, may also …If you need to stop taking Wellbutrin, follow your doctor’s instructions on how to safely stop taking it. They may slowly lower your dose over 6 to 8 weeks to prevent withdrawal symptoms. This is called tapering down. The American Psychiatric Association recommends that all antidepressants be tapered down to lower the risk of withdrawal …Wellbutrin XL tablets: 150 milligrams (mg), 300 mg: General guidelines: The standard starting dose is 150 mg by mouth once daily in the morning.Fluoxetine has an average rating of 7.3 out of 10 from a total of 2166 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 18% reported a negative effect. Wellbutrin XL has an average rating of 7.5 out of 10 from a total of 482 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 15% reported a negative ...Jan 5, 2024 · Eligibility Criteria for Ozempic. Regulating blood sugar in individuals with type 2 diabetes along with diet and exercise. Lowering heart and stroke risks in individuals with type 2 diabetes and ...Jun 27, 2022 ... For instance, she says that if you're taking an SSRI, “switching to fluoxetine [Prozac] could be helpful. Considering a trial of bupropion [ ...Jul 29, 2022 · Fluoxetine: A 2022 review found that in adults with overweight or obesity, taking 60 milligrams (mg) of fluoxetine daily can lead to an average weight loss of 2.7 kilograms (kg) — equivalent to ...Student Organization Resource Center (SORC) Student Conduct. Student Health ServiceMar 23, 2023 · Antidepressants and Weight Loss. Antidepressants linked to weight loss include Prozac (fluoxetine) and Wellbutrin (bupropion). People taking Effexor (venlafaxine) may experience a quick loss of a small amount of weight, and in a 10-year-long study, Effexor was associated with below-average weight gain. A link implies a statistical association ... Wellbutrin has an average rating of 6.7 out of 10 from a total of 742 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 23% reported a negative effect. Vraylar has an average rating of 5.7 out of 10 from a total of 465 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 37% reported a negative effect. The specific starting dosage of Wellbutrin XL for weight loss can vary depending on factors such as your medical history, current medications, and individual needs. Typically, the initial dosage is around 150 mg … ---1